Utility of 18fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma
نویسندگان
چکیده
Utility of fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma S. Horwitz1*, B. Coiffier2, F. Foss3, H. M. Prince4, L. Sokol5, M. Greenwood6, D. Caballero7, F. Morschhauser8, L. Pinter-Brown9, S. P. Iyer10, A. Shustov11, J. Nichols12, J. Balser13, B. Balser13 & B. Pro14 Lymphoma Division, Memorial Sloan-Kettering Cancer Center, New York, USA; Department of Hematology, Hospices Civils de Lyon, Lyon, France; Hematology Department, Yale Cancer Center, New Haven, USA; Division of Cancer Medicine, Department of Haematology, Peter MacCallum Cancer Centre and University of Melbourne, Australia; Department of Malignant Hematology, Moffitt Cancer Center, Tampa, USA; Department of Haematology, Royal North Shore Hospital, Sydney, Australia; Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain; Department of Hematology, Hôpital Claude Huriez, CHU de Lille, France; Division of Hematology-Oncology, UCLA Medical Center, Los Angeles; Malignant Hematology, Houston Methodist Cancer Center, Houston; Division of Hematology, University of Washington, Seattle; JNichols LLC, Swampscott; Veristat, LLC, Holliston; Division of Hematology, Thomas Jefferson University, Philadelphia, USA
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Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive non-Hodgkin lymphomas typically associated with poor prognosis. Most patients with PTCL receive chemotherapy as first-line treatment, but many experience rapid relapse. For patients with relapsed/refractory PTCL, responses to treatment and long-term outcomes tend to worsen with increasing lines of therapy. Romidepsin is a ...
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